Two-component protein-engineered physical hydrogels for cell encapsulation
نویسندگان
چکیده
منابع مشابه
Two-component protein-engineered physical hydrogels for cell encapsulation.
Current protocols to encapsulate cells within physical hydrogels require substantial changes in environmental conditions (pH, temperature, or ionic strength) to initiate gelation. These conditions can be detrimental to cells and are often difficult to reproduce, therefore complicating their use in clinical settings. We report the development of a two-component, molecular-recognition gelation st...
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Covalently-crosslinked hydrogels are commonly used as 3D matrices for cell culture and transplantation. However, the crosslinking chemistries used to prepare these gels generally cross-react with functional groups present on the cell surface, potentially leading to cytotoxicity and other undesired effects. Bio-orthogonal chemistries have been developed that do not react with biologically releva...
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Polymers Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899-8543 Section on Tissue Biophysics and Biomimetics, Laboratory of Integrative and Medical Biophysics, NIH-NICHD, Bethesda, MD 20892 Current address: Department of Biomedical Engineeing, RPI, Troy, New York, 12180 Current address: Department of Polymer Science, University of Akron, Akron, O...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0904851106